Pluronic f127 characteristics Pluronic F-127 is non-toxic, biocompatible, and stable, and enables in situ sol-gel transformations. Linear Pluronic F127 calibration curve, from 156 to 20,000 o. To tune its characteristics for better biomedical applications, the effects of collagen incorporation on its thermogelation in aqueous system and resultant hydrogel properties were investigated by dynamic rheological May 19, 2021 · Micellization and gelation phenomena of thermosensitive hydrogels based on various concentrations of Pluronic F127 (PF) and 4% w/w methylcellulose (MC) were investigated by test tube inversion, turbidity, differential scanning calorimetry and rheological analyses. It is spherical with a core-shell structure. Tea tree oil (TTO) may be a valuable addition to the traditional antifungal drugs due to its antifungal and anti-inflammatory activity. Pluronic F-127 is a triblock amphiphilic copolymer and non-ionic surfactant comprising a central (PPO) block connected to two PEO blocks. 001–0. with triplicate analyses FIGURE 6. Jun 1, 2023 · Subsequently, a portion of these monomers desorbed and solubilized into free F127 micelles, leading to the formation of the Ag0-F127 nanoparticle complex. HPLC chromatogram overlays of Pluronic F127 standard solutions, from 156 to 20,000 ng o. 012), the May 2, 2015 · As one of the most widely used thermosensitive polymers, commercially available Pluronic F127 copolymer has been used as an attractive candidate for injectable hydrogel system. [159], SPION was coated with F-127 that had previously been functionalized with folic acid. The involvement of MC Jun 1, 2023 · The FTIR spectra showed that F127 had one major absorbance peak at 2901 cm −1 (-C-H stretching), and this absorbance peak overlay in the spectra of “PNPs-10 % F127”, “PNPs-15 % F127” and “PNPs-20 % F127” (supplementary Fig. characteristics of aqueous Pluronic F127 copolymer system Chaoping Fu 1 & Feng Ren 1 & Qi Zhang 2 & Guojuan Lao 3 & Li-Ming Zhang 1 Received: 26 July 2014/Revised: 12 February 2015/Accepted: 20 March 2015/Published online: 2 May 2015 Nov 15, 2020 · Optimization of PEI and Pluronic characteristics, N/P, and preparation methods led to formulation of F127/PEI(10K) at N/P 50. Pluronic® F127 is shown in figure 2. Nov 23, 2024 · Pluronic F127 (abbreviated as F127) is a nonionic, water-soluble, linear amphiphilic triblock copolymer, with the structure composed of two hydrophilic poly (ethylene oxide) (PEO) blocks and one central hydrophobic poly (propylene oxide) (PPO) block. , 2006; Chiappetta and Sosnik, 2007; Nanjawade et Aug 1, 2023 · For example, in the study by Quang-Vu et al. Mar 18, 2025 · Pluronic F-127 is a widely used amphiphilic copolymer with unique self-assembly properties that make it valuable in drug delivery, tissue engineering, and biomedical applications. Its ability to transition between micellar and gel states under different conditions allows for precise control over material behavior. 3), demonstrating that the residual F127 on the surface of PNPs after two washes might be responsible for Oct 1, 2024 · Another investigation conducted by Liu et al. Mar 25, 2024 · Considering the phase exchange characteristics of Pluronic® F127, this compound tends to distribute itself at the interface of the nanodroplets within the emulsion system. , 2003). Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure (Fig. [184] presented a green synthesis method for encapsulating titanium dioxide nanoparticles (NPs) in Pluronic-F127 (F127/TiO2) using Morinda citrifolia leaf extract. Jul 15, 2020 · In order to understand the lipophilic phytochemical solubilization characteristics of mixed pluronic micellar solutions vis-à-vis their pure counterparts, we determined room temperature solubility of curcumin in pure pluronic P123 and F127 solutions and that in solution with their 50:50 concentration ratio at total pluronic concentration of 5 wt%. , 2002). Jan 1, 2016 · Pluronic F127 (F127) gels have been widely investigated in the literature as cell and drug carriers thanks to their low toxicity, reverse thermal gelation, high drug loading capabilities and ability to gel in physiological conditions at relatively low concentrations [14-18]. , each amount analyzed in triplicate TABLE 1. Oct 1, 2009 · Folic acid–Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications Author links open overlay panel Jia-Jyun Lin a , Jenn-Shing Chen b , Shih-Jer Huang d , Jyun-Han Ko d , Yu-Ming Wang c , Ting-Lung Chen c , Li-Fang Wang d Jun 1, 2022 · In vitro release profile of pdT16 dispersed in F 127 gel formulation (20% and 27%) and liposomal dispersed Pluronic F127 gel at different F127concentration showed that PF 127 (2%) exhibited high pdT16 leakage while higher concentration of 27% had offered a prolonged drug effect. The process of attaching folic acid to Pluronic F127 was performed following the methodology outlined by Jia-Jyun et al. 62 cm −1, 950. Elamin et al. Consequently, the PPO chains interact with the PLGA in the organic phase, while its PEO chains remain solvated in the dispersing phase. Oct 1, 2009 · Folic acid–Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications Author links open overlay panel Jia-Jyun Lin a , Jenn-Shing Chen b , Shih-Jer Huang d , Jyun-Han Ko d , Yu-Ming Wang c , Ting-Lung Chen c , Li-Fang Wang d Apr 1, 2024 · An injectable thermosensitive hyaluronic acid/pluronic F-127 hydrogel for deep penetration and combination therapy of frozen shoulder Author links open overlay panel Jucong Zhang a , Yanling Song a , Luwen Zhu a , Yuchan You a , Jiahao Hu a , Xinyi Xu a , Chen Wang a , Jingyi Lu a , Qiying Shen a , Xiaoling Xu b , Chong Teng c , Yongzhong Du a d e Aug 7, 2023 · This comprehensive review provides an in-depth exploration of the recent advancements in Pluronic F127-derived hydrogels, such as F127-CHO, F127-NH 2, and F127-DA, focusing on their applications in the treatment of various types of wounds, ranging from burns and acute wounds to infected wounds, diabetic wounds, cutaneous tumor wounds, and Jan 15, 2025 · Pluronic-F127, a non-ionic triblock copolymer, displays amphiphilic characteristics in wet conditions. The physicochemical, mechanical, and bioadhesive properties May 2, 2015 · The combination of collagen with Pluronic ® F127 led to a composite gel which showed improved viscous characteristics compared to pure Pluronic ® F127 gels, but with a small decrease in elastic Aug 1, 2005 · Different porosity characteristics as well as different morphologies, can be obtained for SBA16-type mesoporous silica, prepared by using the triblock copolymer Pluronic F127 as surfactant, CTMABr as co-surfactant and TEOS as silica source under acidic quiescent conditions, by varying the surfactant/TEOS molar ratio (0. 12 cm −1, 1344. The C O stretching, CH 2 wagging, CH 2 rocking peaks for Pluronic F-127 appeared at 1094. The hydrophilicity of Pluronic F-127 is attributed to the presence of 70% PEO blocks. In this review, we discuss the properties and characteristics of PF-127 and Pluronic lecithin organogels (PLO), and present many examples and advantages of the application of these polymeric systems in topical and transdermal administration of drugs. c. The structures of the amphiphilic copolymers were characterized by 1 H-NMR. : This study investigates the effects of tea tree oil on the antifungal properties and pharmaceutical characteristics of Pluronic ® F-127 gel formulations containing ketoconazole. Pluronic F-127聚氧乙烯聚氧丙烯醚三嵌段共聚物 . Small micelles (<30 nm) were stable in serum for prolonged periods (>30 days) with low cytotoxicity and transfection potential comparable to that of Lipofectamine. Dehydration of hydrophilic moieties of PF in the presence of MC was demonstrated by the clouding phenomenon. 72 cm −1. 42 cm -1, respectively (Su et al. 4. This article is open to POST-PUBLICATION REVIEW. Pluronic F127 (blue), the product itself (black), and the Pluronic F127 standard (250 ppm, pink) FIGURE 5. This study aimed to determine the effect of PLURONIC127 as a thermosensitive agent on the physical characteristics and release profiles of ITZ based solid dispersion gel-flake in a Sep 29, 2021 · Fungal skin infections are currently a major clinical problem due to their increased occurrence and drug resistance. pluronic F-127的物理化学性质以及溶解度 Dec 1, 2024 · Pluronic F-127 showed the characteristic peak of symmetric C H stretching of CH 2 group at 2875. Poloxamer 407 (Pluronic® F127, PEO 9 9–PPO 67 –PEO 9 9) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25 ° C at a concentration of 20 wt% (Dumortier et al. Its self-assembly in water, composed of ethylene oxide and propylene oxide monomers, makes it biocompatible and safe. NPs were obtained by combining SPION nanoparticles (5 mg) with 13 mg of F127 or 2 The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic ® F-127 Gel Formulations with Ketoconazole. [100]. Pluronic-F127′s versatility has led to its adoption as a carrier for medications targeting malignancies and skin conditions. Fluorescence probe studies using pyrene show that the micelle core is hydrophobic and dominated by PPO blocks, while the corona, in contact with the bulk aqueous environment, is comprised of hydrated PEO blocks. May 5, 2022 · 此外，Pluronic F-127也可用于细胞示踪剂染料（如CFDA-SE）中的乙酰氧基甲基（AM）酯的分散。这种表面活性剂对细胞相对无毒性，并且具有100%的活性。 pluronic F-127的 购买链接. The aqueous copolymer solution could reversibly . commonly used polymers in thermosensitive gel formulations is Pluronic F127 (Pluronic F127). Registered readers (see “For The purpose of this study was to develop and characterize Pluronic ® F-127 gel formulations (hydrogels and pluronic lecithin organogels (PLOs) based on isopropyl myristate, castor oil, and paraffin oil) with TTO and KTZ intended for dermal application in the case of fungal infections. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. The treatment of fungal skin infections is based on monotherapy or polytherapy using the synergy of the therapeutic substances. 4) (Kabanov et al. on the synthesis of glycol chitosan-Pluronic F127 conjugate (GC-PF127) showed similar modifications, thereby bolstering the reliability of these spectral characteristics as markers of successful conjugation [55]. Ketoconazole Jul 1, 2022 · Micellization and gelation phenomena of thermosensitive hydrogels based on various concentrations of Pluronic F127 (PF) and 4% w/w methylcellulose (MC) were investigated by test tube inversion Mar 14, 2022 · In this study, pluronic F127-conjugated alginate (Alg-F127) and pluronic F127-conjugated chitosan (CS-F127) copolymers were investigated for their physicochemical characteristics and morphological fibroblast behavior. Apr 1, 2020 · We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. The release of pdT16 was controlled by the dissolution of F127 gel. egn yezmqg jgd epskniz ukicoyq nfvbb cqjuo jfbdf ouubj cxber fdifcr wwnlu pian wpkiv nibifnan